Nonequilibrium mechanics and dynamics of motor-activated gels.

نویسندگان

  • F C MacKintosh
  • A J Levine
چکیده

The mechanics of cells is strongly affected by molecular motors that generate forces in the cellular cytoskeleton. We develop a model for cytoskeletal networks driven out of equilibrium by molecular motors exerting transient contractile stresses. Using this model we show how motor activity can dramatically increase the network's bulk elastic moduli. We also show how motor binding kinetics naturally leads to enhanced low-frequency stress fluctuations that result in nonequilibrium diffusive motion within an elastic network, as seen in recent in vitro and in vivo experiments.

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عنوان ژورنال:
  • Physical review letters

دوره 100 1  شماره 

صفحات  -

تاریخ انتشار 2008